Manager Arsene Wenger has done his business early and the 3-0 Community Shield victory over Manchester City last weekend showed that confidence is high in the Gunners camp following their FA Cup triumph in May.
A squad that is no longer burdened by a nine-year trophy drought has been enhanced by the world-class attacking talents of Alexis Sanchez, who joined from Barcelona for a fee in the region of £35m.
Calum Chambers and Mathieu Debuchy have also come in to compensate for the exits of Bacary Sagna and Thomas Vermaelen, but Wenger may feel that his defence is lacking depth, especially with Per Mertesacker not yet available.
There is therefore likely to be a start in midfield for England international Jack Wilshere, who has been criticised by Wenger for his smoking habit and yet backed to have a breakthrough campaign.
Theo Walcott is still over a month away from returning from the anterior cruciate ligament injury that prevented him competing in Brazil, while Serge Gnabry and new goalkeeper David Opsina are doubts for this weekend.
Chambers may be asked to partner Laurent Koscielny at centre-back against a Palace side who scored fewer goals – 33 – than any of the other 16 teams that retained their top-flight status last term.
Palace went on a club-record run of five consecutive wins to help them secure a second successive season in the Premier League for the first time, and co-chairman Steve Parish now has ambitions beyond relegation avoidance.
Palace have not beaten Arsenal in any competition since a 2-1 victory at Highbury in October 1994.
Possible starting lineups
Arsenal: Szczesny; Debuchy, Chambers, Koscielny, Gibbs; Arteta, Ramsey; Cazorla, Wilshere, Sanchez; Giroud
Palace: Speroni; Ward, Hangeland, Dann, Delaney; Puncheon, Jedinak, Ledley, Bolasie; Chamakh, Campbell
Sports Mole says: 2-0