The Gunners, who are currently down in 10th position in the table, have a fully-fit squad for the North London derby, with Emile Smith Rowe recovering from a recent injury to feature in Thursday's 3-1 win over Olympiacos in the first leg of their last-16 Europa League tie.
Arteta is expected to hand a recall to Pablo Mari in the heart of the defence, while Hector Bellerin's speed and experience could see him given the nod over Calum Chambers, who started against Burnley last weekend.
Martin Odegaard, meanwhile, should be given the nod over Smith Rowe in a central position, having played a key role in Thursday's European success.
The only other serious talking point comes on the left, where Willian is battling Nicolas Pepe; the former has been in impressive form in recent games, but Arteta could decide to switch it for the clash with Jose Mourinho's side, allowing Pepe to return to the XI.
Arsenal possible starting lineup: Leno; Bellerin, Luiz, Mari, Tierney; Xhaka, Partey; Saka, Odegaard, Pepe; Aubameyang
Watch the Sports Mole Football Shorts prediction for this game below: