Spurs, who are currently seventh in the table, five points behind fourth-placed Chelsea, are again likely to be without the services of Giovani Lo Celso for this match; the Argentine has recently recovered from a hamstring problem, but a back issue forced him to miss Thursday's 2-0 win over Dinamo Zagreb.
Harry Kane scored twice in the Europa League last-16 first leg at the Tottenham Hotspur Stadium before being forced off in the latter stages of the contest with a knee problem.
Head coach Jose Mourinho is confident that the England captain will be available to start on Sunday, though, with Son Heung-min, Gareth Bale and Lucas Moura likely to join him in the final third of the field.
There will be a number of changes from Thursday's clash, with Matt Doherty, Toby Alderweireld and Sergio Reguilon in line to return to the back four, while Pierre-Emile Hojbjerg will be back in midfield.
Moussa Sissoko and Steven Bergwijn are also options for Mourinho, but the front four is unlikely to be disturbed, with Bale scoring braces in two of his last three Premier League appearances as the Wales international continues to impress after a difficult start to life back at the club.
Tottenham possible starting lineup: Lloris; Doherty, Sanchez, Alderweireld, Reguilon; Hojbjerg, Ndombele; Bale, Lucas, Son; Kane
Watch the Sports Mole Football Shorts prediction for this game below: