The Gunners went down 4-0 to Liverpool in their most recent encounter but have seen off Watford and Aston Villa in North London during their recent resurgence.
Pierre-Emerick Aubameyang has not hit the same goalscoring heights as he did during the early days of his Gunners career, but the Gabon international has developed a fondness for playing the Magpies.
Here, Sports Mole takes a closer look at Aubameyang's record against Newcastle.
Aubameyang's first taste of action versus Newcastle did leave a slightly bitter taste in the mouth, as Arsenal went down 2-1 to the Magpies at St James' Park in April 2018, despite the striker assisting Alexandre Lacazette's opener on the day.
Things would improve for Arsenal against Newcastle during the 2018-19 campaign as the Gunners marched to a pair of 2-1 and 2-0 successes, although Aubameyang failed to score in either game, instead providing one assist for good friend Lacazette in the Emirates win.
The former Borussia Dortmund man would finally open his account in this fixture by scoring the only goal of the game in a 1-0 win at St James' Park on the opening day of the 2019-20 season, and he has gone from strength to strength since.
Arsenal proceeded to crush Newcastle 4-0 at the Emirates later that year as Aubameyang's header opened the scoring before the floodgates opened, and the African's hot streak would continue into 2020-21.
The Gunners' 3-0 win over Newcastle at the Emirates in January saw Aubameyang bag a brace on the day, and nine days before that, he came off the bench to net against the Magpies in the FA Cup.
Aubameyang then scored one and assisted Mohamed Elneny's thunderbolt at St James' Park in Arsenal's most recent meeting with Newcastle back in May, meaning that he heads into Saturday's clash aiming to score for the sixth game in a row against the Magpies.
Since being on the losing side in April 2018, Aubameyang and Arsenal have won their last seven against the St James' Park outfit, with the 32-year-old boasting six goals and three assists from eight appearances in this fixture.
Furthermore, Aubameyang has never failed to register a goal or assist against Newcastle at the Emirates, while Burnley and Tottenham Hotspur (both eight) are the only English sides he boasts more strikes against.