The club's head coach will take encouragement from his side's spirited comeback against Tottenham Hotspur last weekend, but the Portuguese must find a solution to his team's recent struggles at both ends of the pitch.
Nuno has a number of selection dilemmas ahead of the trip to North London, and here Sports Mole looks at how his team could line against Unai Emery's in-form side.
Diogo Jota has fully recovered from an injury to his quad, and that leaves Nuno with a fully-fit squad to choose from for this weekend's fixture.
Nuno has not made a single alteration to his backline in the Premier League this season, but conceding three goals to Spurs last week may lead to Leander Dendoncker being considered for a starting role ahead of Ryan Bennett.
The rest of the team should remain the same, with Morgan Gibbs-White having to make do with a place on the substitutes' bench despite a bright cameo against Spurs.