Only Ainsley Maitland-Niles keeps his place from the XI which began the thrilling Premier League clash at the Emirates Stadium.
Championship side Forest, meanwhile, make just two switches from their goalless draw at Leeds United on New Year's Day.
Nottingham Forest: Smith, Lichaj, Mancienne, Traore, Osborn, Cash, Clough, Brereton, Dowell, Vaughan, Worrall
Subs: Henderson, Mills, McKay, Bouchalakis, Walker, Cummings, Vellios
Arsenal: Ospina, Debuchy, Mertesacker, Holding, Nelson, Willock, Elneny, Maitland-Niles, Walcott, Iwobi, Welbeck
Subs: Macey, Chambers, Osei-Tutu, Dasilva, Reine-Adelaide, Akpom, Nketiah
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