Like their opponents, the Blues were underdogs to progress to this stage of the competition, but victories over Leicester City and Manchester United have put the West Londoners in contention for their ninth FA Cup trophy.
Frank Lampard's team head into the contest on the back of a 2-0 victory over Wolverhampton Wanderers in England's top flight, a result which earned the club a place in next season's Champions League.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of the encounter at Wembley Stadium.
Type of injury: Unknown
Possible return date: August 8 (vs. Bayern Munich)
Although he would not have started, Loftus-Cheek has been dealt another fitness blow after suffering what is described as a minor injury this week. That has led to the academy graduate being ruled out of the contest.
Type of injury: Knee
Possible return date: Unknown
After suffering a significant knee injury against Crystal Palace earlier this month, Gilmour has been ruled out until the end of the autumn at the earliest.
Status: Minor doubt
Type of injury: Knock
Possible return date: August 1 (vs. Arsenal)
Willian was surprisingly left out against Wolves with an unspecified injury. Although the Brazilian is potentially heading for the exit door next week, Lampard has suggested that he has no issues with naming the long-serving playmaker in his squad.
CHELSEA'S SUSPENSION LIST
Chelsea have no players suspended for the meeting with one of their biggest rivals.