Borussia Dortmund, AC Milan and Athletic Bilbao have all exited the Europa League at the last-16 stage following Thursday's second-leg games.
The German giants were unable to find the breakthrough in a goalless draw at Red Bull Salzburg, whose 2-1 first-leg win saw the Austrians reach the quarter-finals of the competition.
Milan, meanwhile, slumped to a 3-1 defeat at Arsenal which, combined with their 2-0 first-leg defeat, sent the Italian giants crashing out of the competition by a heavy 5-1 aggregate scoreline.
Athletic were aiming to overturn a 3-1 first-leg deficit against Marseille at San Mames but lost 2-1 in a return encounter marred by crowd trouble.
The Portuguese giants progressed as Rodrigo Battaglia's 105th-minute goal was enough for a 3-2 aggregate win, even if they did lose 2-1 on the night.
Results in full: Lokomotiv Moscow 1-5 Atletico Madrid, Athletic Bilbao 1-2 Marseille, Dynamo Kiev 0-2 Lazio, Zenit St Petersburg 1-1 RB Leipzig, Viktoria Plzen 2-1 Sporting Lisbon, Arsenal 3-1 AC Milan, Lyon 2-3 CSKA Moscow, Red Bull Salzburg 0-0 Borussia Dortmund