Chelsea vs. Southampton (Tuesday, 7.45pm)
The Blues will enter the contest off the back of a 7-0 win over Norwich City in the league on Saturday, while Southampton played out a 2-2 draw with Burnley on the same afternoon.
We say: Chelsea 2-0 Southampton
Both teams will make wholesale changes from their league matches at the weekend, and we are expecting Chelsea's second string to be too strong for Southampton, who simply cannot call upon the same quality in reserve as their opponents here.
Arsenal vs. Leeds (Tuesday, 7.45pm)
The Gunners will enter the contest off the back of a 3-1 win over Aston Villa in the Premier League on Friday, while Leeds played out a 1-1 draw with Wolverhampton Wanderers on Saturday.
We say: Arsenal 2-1 Leeds United
It is difficult to know exactly what to expect at the Emirates Stadium, as neither side will be at full strength. Arsenal are on a bit of a roll at the moment, though, and we are backing the Gunners to edge their way into the quarter-finals of the League Cup courtesy of a narrow success.
QPR vs. Sunderland (Tuesday, 7.45pm)
Both Queens Park Rangers and Sunderland will be hoping to bounce back from weekend defeats by progressing to the quarter-finals of the EFL Cup on Tuesday evening at the Kiyan Prince Foundation Stadium.
The hosts slipped out of the playoff places in the Championship as a result of their loss, whilst their League One visitors still find themselves sitting in fourth in the division below despite the setback.
We say: Queens Park Rangers 2-1 Sunderland
Sunderland are likely to provide a tough test for their Championship opponents on Tuesday, but with home advantage adding to the extra quality available to the hosts, QPR should come out victorious here.
The number of changes that each side make could prove to be key as well, although neither are likely to play a drastically weakened team with a quarter-final spot awaiting the winners.