Arsenal and Lille have confirmed their starting lineups for Tuesday's Champions League league-phase clash at the Emirates Stadium.
Gunners boss Mikel Arteta was dealt two fresh injury blows ahead of the visit of Les Dogues, as Piero Hincapie and Martin Zubimendi suffered ankle injuries in the warm-down to Saturday's 2-1 Premier League win over Leeds United.
Both Hincapie and Zubimendi would have been candidates to start against Davide Ancelotti's side, but Arteta has nevertheless made five changes to his XI from the weekend.
Despite Hincapie's absence, Riccardo Calafiori is still granted the night off from left-back duties, as Myles Lewis-Skelly has reverted to a defensive role.
On the other side of the backline, Jurrien Timber steps in for Ben White, while Lewis-Skelly starting at left-back has opened the door for Bruno Guimaraes to join captain Declan Rice in midfield.
Further forward, Mikel Merino is expected to operate in the number 10 role in Martin Odegaard's place, while Eberechi Eze and Viktor Gyokeres have also been promoted to the first XI.
Noni Madueke holds his spot in the side, though, and will switch over to the right flank in place of Bukayo Saka, who is on the bench alongside Kai Havertz.
Cristhian Mosquera has also made a matchday squad for the first time since picking up a hamstring injury against Aston Villa in August, while Max Dowman, Marli Salmon and 18-year-old midfielder Malik Hashi are among the substitutes.
Arsenal vs. Lille lineups confirmed: Olivier Giroud on bench for Les Dogues
As for Lille, Ancelotti has also made five alterations to his starting lineup from the weekend's Ligue 1 success over Le Havre, one of which sees ex-Gunners striker Olivier Giroud dropped to the dugout.
The 40-year-old makes way for star striker Ayase Ueda, who is joined in the four-pronged attack by Nottingham Forest loanee Dilane Bakwa and highly-rated Icelandic playmaker Hakon Arnar Haraldsson.
Benjamin Andre - the only surviving member of Lille's 2020-21 Ligue 1-winning squad - is also restored to the midfield, alongside ex-Tottenham Hotspur man Andre Bentaleb.
Meanwhile, defender Tiago Santos is out after tearing his ACL at the weekend, so Maxima Goffi starts at right-back, while Nathan Ngoy returns at centre-back after being rested against Le Havre.
Arsenal XI: Raya; Timber, Konsa, Gabriel, Lewis-Skelly; Rice, Guimaraes; Madueke, Merino, Eze; Gyokeres
Subs: Kepa, Mosquera, White, Saka, Odegaard, Havertz, Calafiori, O'Neill, Dowman, Hashi, Salmon
Lille XI: Ozer; Goffi, Ngoy, Alexsandro, Perraud; Andre, Bentaleb; Bakwa, Haraldsson, Mukau; Ueda
Subs: Gill, Sajous, Srdanovic, Giroud, Sahraoui, Kjaergaard, Onal, Nianzou, Verdonk, Cossier, Perrin, Diaoune