Fiorentina vs. Napoli (Sunday, 11.30am)
While the fourth-placed Partenopei must win to keep pace with several others in pursuit of Champions League football, their hosts have only just secured a Serie A spot for next season following a forgettable campaign.
We say: Fiorentina 1-3 Napoli
With a return to Europe's top table now in sight, Gennaro Gattuso has got his Napoli squad operating at maximum capacity. So, with Victor Osimhen and Lorenzo Insigne - who loves to score against Fiorentina - in fine form up front, the Azzurri should post an 11th win in 15 league games.
Fiorentina, meanwhile, have nothing left to play for beside pride and possible future employment, with Gattuso a potential candidate to take the helm at the underperforming club next season. Their five-game unbeaten run is therefore set to end on Sunday.
Benevento vs. Crotone (Sunday, 2.00pm)
Gli Stregoni sit 18th in the table with just two games left to play and are four points behind closest rivals 16th-placed Torino and 17th-placed Spezia, who both have a better goal difference and play each other on Saturday.
We say: Benevento 2-1 Crotone
It is do or die for Benevento as relegation edges ever closer, but we think they will take the battle to the final day of the campaign with victory in this game. Crotone, despite their win on Thursday, have been abysmal this season and are the perfect opponent for Inzaghi's side to break their horrendous run of form against.
Udinese vs. Sampdoria (Sunday, 2.00pm)
With both clubs sitting safely in the middle of the standings ahead of the penultimate game of the season, only a top-half finish is at stake for two sides separated by six points.
We say: Udinese 1-2 Sampdoria
As Udinese's form has been tailing off for some time - perhaps since they effectively sealed safety last month - they are unlikely to turn it around against a Sampdoria side who can be surprisingly potent on their day.
The visitors, then, can make use of their superior attacking options to seal their top-half spot with a fourth win in seven games.
Parma vs. Sassuolo (Sunday, 5.00pm)
An Emilian derby - which will be put on pause for at least one season, as the hosts head for the second tier next term - sees Roberto De Zerbi's visitors still chasing a top-seven finish, which would secure their return to European football.
We say: Parma 1-2 Sassuolo
For all their miserable results - most notably during the last two months - Parma have often pushed opponents hard, before committing another calamitous mistake or losing discipline at the back.
As they prepare for life in Serie B, then, they can test Sassuolo's sometimes vulnerable rearguard on Sunday, but will ultimately be unable to resist their visitors' in-form strikeforce for a full 90 minutes.
AC Milan vs. Cagliari (Sunday, 7.45pm)
In need of the points for very different reasons, the clubs meet at San Siro, both sitting near the top of the recent form table.
We say: AC Milan 2-0 Cagliari
Suddenly firing on all cylinders again, as if lockdown had just been lifted, Milan can finish the first half of 2021 in similar fashion to their stratospheric re-start form last year.
With confidence coursing through the Rossoneri veins, even a recently resurgent Cagliari cannot deny them a deserved shot at the big time next term - earned by merit, rather than breaking away into an ill-conceived league of their own.