Spezia vs. Crotone (Saturday, 2.00pm)
Pitting together two of the teams promoted to the top flight last year, three points from this encounter could go a long way to ensuring the hosts' survival, while their hapless visitors from Calabria need both a win and a miracle to avoid demotion in May.
We say: Spezia 1-2 Crotone
Cosmi's Crotone can pick up just their fifth win of the season, which may come too late to stoke realistic ambitions of survival, but could pull their erstwhile Serie B colleagues Spezia closer within range.
The visitors' goalscoring potential now matches that of their hosts and the Bianconeri are still flaky at the back due to a progressive policy which does not always bear fruit - as they average barely over a goal per game at home this term.
Parma vs. AC Milan (Saturday, 5.00pm)
With the second-placed Rossoneri now 11 points adrift of table-topping rivals Inter, their thoughts have turned to keeping the closing pack at bay, while their Emilian hosts are in deep trouble near the bottom of the standings with games running out.
We say: Parma 2-3 AC Milan
As Parma have finally found their shooting boots - averaging two goals per game across their last four outings - they can definitely rattle an increasingly fragile Milan side on Saturday.
Nevertheless, all their attempts to at least replicate the autumn's 2-2 draw between these sides could come to naught if Milan's potent front four can continue their ruthless away form at the Tardini.
Udinese vs. Torino (Saturday, 7.45pm)
Their hosts' improved fortunes in the second half of the season, meanwhile, have afforded them a potentially serene conclusion to their Serie A campaign despite suffering back-to-back losses in recent weeks.
We say: Udinese 1-2 Torino
Torino's desperation to claw their way closer to safety could work for them or even against them versus a more relaxed and occasionally dangerous Udinese side this weekend.
However, the Granata's goal threat has increased significantly since 'Tonny' Sanabria came into the XI, and the Paraguayan marksman can inspire his fellow forwards - including club captain and top scorer Andrea Belotti - to chip in with some vital returns at the Friuli.