However, Bratislava make the trip to Molineux sitting just two points adrift of Wolves in Group K, while also being keen to avenge the 2-1 defeat which they suffered against the English clubs two weeks ago.
Having played four successive away games in all competitions, Nuno Espirito Santo and his players would have been relieved to return to home comforts this week ahead of another important double-header in their two priority competitions.
However, Wolves' recent results suggest that they are better equipped to earn results on their travels, with wins coming in Turkey against Besiktas and Slovakia versus their opponents on Thursday.
Saturday's 1-1 draw at Arsenal was also a notable result as Wolves look to move away from the Premier League relegation zone, but Nuno is aware that his side must deliver more victories in front of their own supporters.
Nevertheless, having only played one fixture at Molineux since September 28, the break away from familiar surroundings may benefit Wolves with Nuno continuing to search for combinations which can aid his team at both ends of the pitch.
Whether they can overcome a united Bratislava side for the second time in quick succession remains to be seen, although the opportunity is there for Wolves to move just a point away from progressing through to the last 32.
While Bratislava would have been hugely disappointed to let slip a half-time lead against the Premier League side last month, Jan Kozak will still be satisfied with where his team find themselves at the midway point of the group.
With a home game with leaders Braga still to come, Kozak will acknowledge that a positive result this week could make all the difference as Bratislava look to earn a rare appearance in the latter stages of a European competition.
Since the last meeting with Wolves, wins and clean sheets over Zemplin Michalovce and Senica have kept the club five points clear at the top of their domestic table.
Wolverhampton Wanderers form: WDWDLD
Slovan Bratislava form: WWWLWW
Barring any late injury concerns, Kozak could name the same XI which began the first game after resting a number of players at the weekend.
Wolverhampton Wanderers possible starting lineup: Patricio; Bennett, Coady, Saiss; Jonny, Dendoncker, Moutinho, Neves, Vinagre; Cutrone, Jimenez
Slovan Bratislava possible starting lineup: Greif; Medvedev, Abena, Bozhikov, Vernon; Kamps, Rabiu; Daniel, Holman, Rharsalla; Sporar
We say: Wolverhampton Wanderers 1-1 Slovan Bratislava
Like in Slovakia, we expect this contest to be a closely-fought affair. The game is set up for Wolves to complete the double over Bratislava, although we expect the visitors to earn a share of the spoils in the West Midlands.