The duo were excluded for the 3-2 victory over Leeds United last week in light of reports that the pair were embroiled in a scuffle on the training ground.
Robins initially cited "tactical reasons" as the motive behind their omission, but both are poised to miss out again having failed to make the squad for the trip to the DW Stadium.
Jon Stead, who fired the winner against Leeds, continues to deputise for leading goalscorer James Vaughan, who serves the second of his three-match ban, while Duane Holmes drops to the bench in favour of Oliver Norwood.
Wigan Athletic: Nicholls; Shotton, Boyce, Perch, Barnett; McCann, Watson, Powell, McManaman, Fortune; Gomez
Huddersfield Town: Smithies; Richards, Clarke, Dixon, Lynch; Hammill, Hogg, Southern, Norwood; Ward, Stead