The Latics currently sit seven points behind sixth-placed Reading, but their recent form, coupled with two games in hand, suggests that they could be in line to make a late charge for the playoffs.
Wigan could move as high as seventh with a win on Saturday, although they would also need other results to go their way and a six-goal swing between themselves and Ipswich Town.
The hosts have a good home record to fall back on having lost just twice at the DW Stadium in their 13 Championship matches there this season, although five of the remaining 11 games have ended in draws.
The Latics have kept clean sheets in five of their last six Championship games, but only two teams outside the bottom three have scored fewer goals than them this season.
That didn't seem to trouble them in their last home outing in the league, however, as they cruised to a 3-0 win over Bournemouth.
Looking for a repeat of that performance, Rosler could name Nick Powell and Nicky Maynard in the same lineup for the first time as he has a fully fit squad to choose from apart from long-term absentees Shaun Maloney and Gary Caldwell.
Charlton are in desperate need of three points themselves having slipped into the relegation zone following a run of just one win in 10 matches.
Their survival hopes have taken a blow from the improved form of the teams around them, and they are now two points adrift of safety.
Chris Powell's side did make it into the fifth round of the FA Cup last weekend courtesy of a 1-0 win over Huddersfield Town, but they were brought crashing back down to earth with a 3-0 defeat at the hands of fellow strugglers Doncaster Rovers on Tuesday.
The Addicks have gone seven games without a win on their travels in the league, while they have only managed to pick up maximum points twice all season, giving them the joint third worst away record in the division.
Possible starting lineups
Wigan: Al-Habsi; Perch, Barnett, Boyce, Beausejour; McArthur, Watson; McClean, Powell, McManaman; Maynard
Charlton: Alnwick; Solly, Morrison, Wood, Wiggins; Harriott, Jackson, Stephens, Cousins; Kermorgant, Church
Sports Mole says: 3-1