The Latics have fallen down the Championship table in recent weeks, while they were eliminated from the Europa League on Thursday night, and new boss Uwe Rosler could have a tough job on his hands to turn things around at the DW Stadium.
The former Brentford manager could recall Grant Holt, after the striker sat out of Wigan's trip to Maribor in Europe.
Bolton recovered from two consecutive losses to record a comfortable 3-0 triumph over Doncaster Rovers last weekend.
Manager Dougie Freedman spoke highly of his team's performance at the Reebok Stadium, and that could see the 39-year-old retain the same starting lineup.
Wigan Athletic: LLLLLL
Bolton Wanderers: WWWLLW
Possible starting lineups
Wigan Athletic: Carson; Boyce, Crainey, Ramis, Barnett; Watson, McManaman, McCann, McArthur; Powell, Holt
Bolton Wanderers: Lonergan; McNaughton, Baptiste, Mills, Ream; Spearing, Lee, Pratley, Moritz, Eagles; Mason
Sports Mole says: 1-2