Hammers boss Sam Allardyce has a host of new signings to consider for the match, including goalkeeper Jussi Jaaskelainen, Alou Diarra, Mohamaed Diame and Modibo Maiga, who could all contest for a starting spot.
Jack Collison is expected to miss out on his side's opener due to a knee injury that was aggravated in pre-season, while skipper Kevin Nolan should be fit to lead his side out after overcoming a toe problem.
The Scottish boss has been forced to deal with the losses of Marc Albrighton, Gabriel Agbonlahor and Richard Dunne, who all face lengthy spells on the sidelines due to their respective injury problems.
West Ham: Jaaskelainen; Demel, Reid, Collins, O'Brien; Tomkins, Diame, Noble, Vaz Te; Maiga, Cole
Aston Villa: Given; Lichaj, Clark, Vlaar, Bannan; Ireland, El Ahmadi, Delph, N'Zogbia; Bent, Weimann
Sports Mole says: 1-1