Modibo Maiga, Morgan Amalfitano and Mauro Zarate have therefore been selected to lead the line in a team that shows seven changes from last time out, as the Hammers aim to take a convincing lead into next week's reverse leg.
There is also a place in the starting lineup for Kevin Nolan, who has been handed the captain's armband by Bilic in the middle of the park, but new signing Stephen Hendrie has to make do with a place among the subs.
West Ham United:: Adrian, O'Brien, Reid, Tomkins, Cresswell, Noble, Nolan, Jarvis, Amalfitano, Zarate, Maiga
Subs: Randolph, Collins, Poyet, Hendrie, Samuelsen, Lee, Pike
Birkirkara: Haber, Muscat, Zerafa, Mazzetti, Vukanac, Camenzuli, Fenech, Muscat, Liliu, Miccoli, Murga
Subs: Agius, Akpan, Aquilina, Plut, Sciberras, Zammit, Zerefa