Chris Coleman's Welshmen have had a torrid run up to this evening's bout after failing to win a single game in their qualifying group, while the Scots currently sit fourth in the standings with two points.
Craig Levein welcomes Sunderland striker Steven Fletcher back into the fold after successful clear-the-air talks earlier this month but the former Wolverhampton Wanderers forward is likely to be handed a spot on the bench.
Manchester United midfielder Darren Fletcher is likely to be given a starting place after returning to the field last month, despite dealing with a chronic bowel condition.
Wales: Brown; Matthews, Williams, Nyatanga, Gunter; Allen, Ledley, Ramsey, Bale; Morison, Vokes
Scotland: McGregor; Hutton, Caldwell, Berra, Mulgrew; Morrison, D Fletcher, Adam, Commons; Brown; Miller
Sports Mole says: 1-1