The Yellow Submarine will enter the contest off the back of a 2-0 defeat to Sevilla, while Levante won a seven-goal thriller against Real Betis to make it three victories in their last four matches.
The Yellow Submarine currently occupy fifth position, having picked up 26 points from their 16 matches this season courtesy of six wins and eight draws.
Recent injury problems have harmed Unai Emery's side, and they have actually only won one of their last seven in Spain's top flight, sharing the points in five of those encounters.
Villarreal have finished fifth in three of their last four campaigns and last claimed fourth in 2015-16; there is a lot of competition for the Champions League places in La Liga, but El Submarino Amarillo will certainly be eyeing another top-four spot in the second half of the campaign.
Levante, meanwhile, will enter this weekend's contest off the back of a 4-3 win over Betis on Tuesday night; Manuel Pellegrini's side scored twice in the latter stages to set up a grandstand finish, but the home team held on to claim another three points, which moved them into 12th position.
The Frogs have now won three of their last four matches in all competitions, including an impressive 2-1 home success over Real Sociedad on December 19.
The visitors will therefore enter this match full of confidence and knowing that a victory could see them move into the top half of the division depending on other results.
Levante suffered a 2-1 defeat to Villarreal when the two teams last locked horns at Estadio de la Ceramica but recorded a 2-1 victory when the pair met in Valencia in the reverse match.
Villarreal La Liga form: DDDWDL
Villarreal form (all competitions): DDWWDL
Levante La Liga form: DWLWDW
Levante form (all competitions): WLWWDW
Carlos Bacca did feature as a substitute against Sevilla last time out, though, and the Colombia international could now be in contention to earn a starting role in this match.
As for Levante, Nikola Vukcevic, Enis Bardhi, Sergio Postigo and Jose Campana are again expected to miss out through injury, while Ruben Vezo is still unavailable following a positive coronavirus test.
Villarreal possible starting lineup:
Asenjo; Pena, Albiol, Torres, Estupinan; Trigueros, Parejo, M Gomez; Pedraza, Bacca, G Moreno
Levante possible starting lineup:
Aitor; Miramon, Duarte, Clerc, Coke; De Frutos, Malsa, Radoja, Morales; D Gomez, Marti
We say: Villarreal 2-1 Levante
Levante's recent form must be respected, with Lopez's side losing just one of their last 10 in the league; they have struggled on the road, though, winning just one of their last eight, and we fancy Villarreal to claim all three points courtesy of a narrow success.