Both sides occupy playoff places, but they are far from secure with Vancouver Whitecaps occupying the seventh and final playoff position, while their opponents sit a place higher in sixth place in the Eastern Conference.
Vancouver head into Wednesday in seventh place, but they are only two points clear of Real Salt Lake, who have a game in hand.
Therefore, the midweek clash with Minnesota is crucial if Vancouver are to remain in the playoffs, and they enter the encounter in the midst of a three-match unbeaten run.
In fact, the Caps have only lost once in their last eight fixtures and, in their most recent outing, they drew 1-1 with San Jose Earthquakes.
Vanni Sartini will be confident that his side can get a win on Wednesday, with Vancouver winning seven of their previous 10 home games, and they have only suffered one home defeat in that period.
Minnesota will be aware that a win away to Vancouver on Wednesday would help cement their place in the playoffs, and like their opponents, they enter the fixture unbeaten in their last three contests.
After beating Austin FC 1-0 and edging out Philadelphia Union thanks to a 3-2 scoreline, Minnesota hosted Los Angeles FC at the weekend.
Wednesday's visitors have been in fine goalscoring form of late, netting in seven of their last eight games but five of those encounters were at home.
That will be a concern for head coach Adrian Heath, with Minnesota only scoring two goals in their last five away matches.
Caio Alexandre is also still missing for the hosts with an ankle injury.
Meanwhile, Jake Nerwinski was dropped for the weekend encounter with San Jose Earthquakes, but the defender is likely to return to the starting lineup on Wednesday.
Minnesota will have Romain Metanire back available after serving a one-match suspension, and he will come back into the starting lineup.
Metanire's return will see Hassani Dotson move from right-back to the more familiar surroundings of midfield.
Robin Lod came into the starting lineup against Los Angeles FC, and the Finnish international is set to keep his place in the side.
Vancouver Whitecaps possible starting lineup:
Crepeau; Nerwinski, Veselinovic, Jungwirth; Gaspar, Teibert, Owusu, Dajome; Gauld, White, Caicedo
Minnesota United possible starting lineup:
Miller; Metanire, Boxall, Dibassy, Gasper; Trapp, Dotson, Reynoso; Lod, Fragapane, Hunou
We say: Vancouver Whitecaps 1-1 Minnesota United
It is difficult to choose between the two teams, with both sides so close in the standings, and with only three games remaining in the regular season no side will want to lose this encounter, which is why we think it will end all square.