Klinsmann suggested that the MLS is having a negative effect on the national squad because it is "difficult" to maintain the same standard that is seen in European leagues.
Garber believes that the US boss has taken the wrong approach, however, hitting back at the "negative" remarks.
"I feel very strongly, having spent the last 24 hours thinking about this issue, that Jurgen's comments are very detrimental to the league," FourFourTwo quotes the 57-year-old as saying.
"Sending a negative message to any players that signing with MLS is not good for career or form is incredibly detrimental to US soccer. I believe that it sends the wrong message to other young American players. I also think it's going to send the wrong message to players we're trying to sign from overseas."
The USA played out a 1-1 draw with Honduras in their last outing.