Both sides come into the match needing a win after losing their respective opening fixtures.
However, Cavani believes that the Uruguayans must be fully concentrated if they want to get a positive result against the Three Lions in Sao Paulo.
"Keeping our concentration will be key," he told FIFA.com. "We cannot make mistakes because another defeat would be too much against rivals of this quality, but I believe it's exactly that which will allow us to quickly regain our morale.
"We face England and then Italy, not just any old teams, and we have to beat them."