Frank de Boer's men are favourites to finish top of the standings, while Turkey are second seeds and are much fancied to join their opponents in Qatar next year.
De Boer's first couple of months in the job did not exactly get off to a flyer, with the Oranje losing a friendly against Mexico and drawing their next three games.
However, it must be factored in that they earned draws against Italy and Spain in that run, before then beating Bosnia-Herzegovina and Poland to end 2020 on a high.
The Dutch are therefore unbeaten in five matches and have this summer's rescheduled Euro 2020 tournament to look forward to.
Finishing top of Group G in this next qualifying campaign will be the target for De Boer, but his side begin with what on paper is their toughest match of the whole campaign.
Turkey lost 2-0 to Hungary in their most recent outing, though that came on the back of a six-game unbeaten streak.
That includes a run of five draws, holding Germany and Croatia 3-3 across that period.
In fact, going further back, the Crescent-Stars have lost only three of their last 21 competitive and non-competitive matches, seeing them rise to 32nd in the FIFA rankings.
Senol Gunes's charges, like the Netherlands, will compete in this summer's Euros in a group that also contains Italy, Wales and Switzerland.
Using the momentum from their last campaign, Turkey will be looking to reach their first World Cup finals since 2002, when famously going on to finish third.
The last meeting between these nations was a European Championship qualifier in September 2015, which Turkey won 3-0 on home soil.
The Netherlands were expected to be without one of their key men, Lyon forward Memphis Depay, due to restrictions imposed by the French government on travelling during the coronavirus pandemic.
However, it has since been confirmed that Depay has been given the all clear to link up with his nation side due to the French government making an exception to the mandatory quarantine regulation.
Turkey possible starting lineup:
Gunok; Celik, Soyuncu, Demiral, Erkin; Yazici, Turfan, Yokuslu, Calhanoglu, Karaman; Tosun
Netherlands possible starting lineup:
Cillessen; Dumfries, De Ligt, Blind, Wijndal; De Jong, Klaassen; Berghuis, Wijnaldum, Depay; De Jong
We say: Turkey 1-1 Netherlands
The Netherlands' form picked up at the end of 2020 and they are unbeaten in five heading into this new qualifying campaign.
However, Turkey are themselves on a good run, even accounting for a 2-0 loss against Hungary last time out, and have showed over the past two years they can hold the elite nations to a draw.
With that in mind, we are tipping this clash between Group G's top two seeds to finish all square.