Paolo Di Canio's side are progressing impressively in League One, their 4-0 away defeat of Stevenage on Saturday taking them to within just six points of the top.
Swindon defeated Championship side Burnley 3-1 at home in the third round in September, and the County Ground faithful will be cheering the team for more success against opposition from the higher league.
Villa manager Paul Lambert will hope to use their League Cup campaign as a welcome distraction from the turmoils in the Premier League.
The Villans are just two points and one place above the relegation zone, and have not won a single competitive match since their 4-2 extra-time defeat of Manchester City in the third round of the League Cup in September.
Swindon Town: WDDLW
Aston Villa: LDLLD
Possible starting lineups:
Swindon Town: Foderingham, Flint, Devera, Ward, Ritchie, McCormack, Miller, Bostock, Benson, Storey, Rooney
Aston Villa: Given, Vlaar, Lichaj, Herd, Lowton, El Ahmadi, Albrighton, Holman, Delph, Agbonlahor, Bent
Sports Mole says: 3-2