Both sides are under new permanent managers and lost several of their best players over the summer, but currently occupy top-four positions in the table.
Swansea saw their 100% start to the campaign ended by Chelsea last weekend, but not before they had given the title favourites a scare by leading into first-half stoppage time at Stamford Bridge.
The Saints have reacted very well to their difficult transfer window and have picked up seven points from their last three games to calm talk that they may be involved in a relegation battle this term, following an exodus of five key players.
Target man Pelle netted a brace in the 4-0 thrashing of Southampton last Saturday, in which Jack Cork also scored, and the midfielder is playing himself towards a new contract at the South Coast club.
On-loan Atletico Madrid defender Toby Alderweireld was a debutant in that victory and should continue in what is likely to be an unchanged Southampton starting XI for their trip to the Liberty Stadium.
The Belgian's fellow deadline-day arrival Sadio Mane could be included on a Saints bench which will also feature Victor Wanyama and James Ward-Prowse, and arguably possesses more depth than it did last term.
The injury to Amat will allow Monk to hand a full debut to Argentine international defender Federico Fernandez alongside Ashley Williams, in what could be one of two changes made from the Chelsea defeat.
Having been left on the bench last weekend as a result of a late return from Ivory Coast duty, Wilfried Bony, still looking for his first goal this campaign, could be recalled in attack at the expense of Bafetimbi Gomis.
The Saints have not lost any of their last five matches against the Swans and have kept three clean sheets in that run.
Possible starting lineups
Swansea: Fabianski; Rangel, Williams, Fernandez, Taylor; Ki, Shelvey; Routledge, Sigurdsson, Dyer; Bony
Southampton: Forster; Clyne, Fonte, Alderweireld, Bertrand; Cork, Davis, Schneiderlin; Tadic, Pelle, Long
Sports Mole says: 2-1