The club's manager told reporters: "[Vazquez] got close against Valencia. He had one saved on the line and one legal goal which was not given.
"I'm pleased with his performances in the two games and I think he will do the same again on Wednesday. Sometimes in the moments where you do have injury problems the other players give a little extra, and that's what has happened here as well.
"As a manager you always want as many players available as possible but injuries are a part of football as it is a contact sport."
Vazquez, who is on loan from Getafe, is yet to score for Swansea despite making 11 appearances for the Welsh side.