January arrival Manolo Gabbiadini is the only member of the front three to retain his place in the lineup after scoring in the 3-1 defeat to West Ham United last weekend, with Redmond and Tadic coming in for the injured Sofiane Boufal and Jay Rodriguez, who starts on the bench.
For the hosts, David Moyes is forced into one change from the side that claimed a morale-boosting rout of relegation rivals Crystal Palace last time out.
Sunderland: Mannone; Kone, O'Shea, Denayer; Jones, Ndong, Gibson, Larsson, Oviedo; Januzaj, Defoe
Subs: Mika, Manquillo, Borini, Pienaar, Khazri, Lescott, Honeyman
Southampton: Forster; Cédric, Stephens, Yoshida, Bertrand; Romeu, Davis, Ward-Prowse; Tadić, Redmond, Gabbiadini
Subs: Hassen, Gardos, McQueen, Hojbjerg, Sims, Long, Rodriguez