Steven Pienaar misses out for the hosts due to suspension, with Jason Denayer coming in to take his place in David Moyes's sole alteration from their victory over Bournemouth last time out - their first of the season.
Victor Anichebe is able to start despite suffering from cracked ribs during the Bournemouth game.
Sunderland: Pickford; Jones, Kone, Djilobodji, Van Aanholt; McNair, Denayer; Anichebe, Ndong, Watmore; Defoe
Subs: Mannone, Khazri, O'Shea, Manquillo, Love, Januzaj, Gooch
Hull City: Marshall; Tymon, Dawson, Davies, Elmohamady; Livermore, Mason, Clucas, Snodgrass; Henriksen, Mbokani
Subs: Maguire, Meyler, Huddlestone, Jakupovic, Weir, Bowen, Olley.