The former Championship outfit are just one point above this weekend's rivals due to clinching just two victories in their last six games, but they can strengthen their position in the table with three away points.
Danny Graham has had a tough start to his career at Sunderland, but the striker will look to end his goal drought if selected by Di Canio.
Possible starting lineups
Sunderland: Mignolet; Bardsley, O'Shea, Cuellar, Rose; N'Diaye, Vaughan; Johnson, Larsson, McClean; Graham
Southampton: Boruc; Clyne, Yoshida, Hooiveld, Shaw; Davis, Schneiderlin, Cork; Lallana, Lambert, Rodriguez
Sports Mole says: 1-1