The Black Cats will head into this fixture off the back of a goalless draw at Stoke City in the Premier League on Saturday, and have lost just one competitive game so far this season.
However, Middlesbrough are likely to prove a difficult side to beat, especially as they have won their last four matches in the Championship.
There are no fresh injury concerns for either side. Scott McDonald is likely to partner Ishmael Miller in attack for the visitors.
Possible starting lineups:
Sunderland: Mignolet; Rose, Gardner, O'Shea, Cuellar; Cattermole, Colback, Johnson, McClean; Larsson, Fletcher
Middlesbrough: Steele; Amougou, Friend, Hines, Parnaby; Leadbitter, McEachran, Reach, Haroun; McDonald, Miller
Sports Mole says: 2-1