Jonny and Neto are facing several months on the sidelines due to serious knee injuries, but the Portuguese pair both recently underwent successful operations and will be hopeful of returning to action in the opening months of next season.
Jimenez, meanwhile, has not played any minutes since sustaining a serious head injury against Arsenal in late November, but the Mexico striker has returned to non-contact training.
Wolves manager Nuno Espirito Santo revealed during his pre-match press conference on Friday that the club are set to receive an update on May 18 regarding how quickly Jimenez may be able to take to the field again, with returning to full contact training likely to be the next stage of his rehabilitation.
In more positive news, Willy Boly and Fernando Marcal both returned to training earlier this week, but the pair are unlikely to be risked from the start against Spurs. Wednesday's trip to Everton could be a more realistic return date for the pair should Nuno look to provide them with some match fitness.
Likewise, Owen Otasowie should be a part of the squad once again after missing out on last weekend's win against Brighton & Hove Albion with a minor knock sustained against West Bromwich Albion.
Max Kilman and Ki-Jana Hoever received surprise starts in defence against Graham Potter's side and will hope to keep their places in the starting line up, but midfielder Vitinha is likely to drop to the bench in place of Adama Traore, who impressed with a goal against the Seagulls.
Wolves possible starting lineup: Patricio; Hoever, Coady, Kilman, Ait-Nouri; Dendoncker, Neves, Moutinho; Traore, Silva, Podence
Watch the Sports Mole Football Shorts prediction for this game below: