The 27-year-old missed the last league match against Southampton with an ankle problem but returned to action in the EFL Cup final last weekend and is set to remain in the starting lineup.
Full-backs Ben Davies (calf) and Matt Doherty (muscle) are both set to miss out with injuries, which could therefore see interim boss Ryan Mason start the same back four that he named for his first two games in charge.
Serge Aurier, Toby Alderweireld, Eric Dier and Sergio Reguilon are set to shield club captain Hugo Lloris in goal, while midfielders Harry Winks and Pierre-Emile Hojbjerg could also keep their places in the starting lineup.
Dele Alli will be hoping for more regular game time in the post-Mourinho era and a game against the league's lowest ranked side could be a good fixture for Mason to hand the midfielder a start.
Kane is set to be joined in attack by Son Heung-min, who scored the winning penalty against the Saints in Tottenham's last Premier League outing, while Lucas Moura could face competition from Gareth Bale and Erik Lamela to keep his place in the first XI.
Tottenham possible starting XI: Lloris; Aurier, Alderweireld, Dier, Reguilon; Hojbjerg, Winks; Bale, Lo Celso, Son; Kane
Watch the Sports Mole Football Shorts prediction for this game below: