Spurs have been criticised for not substituting the Frenchman after his collision with Romelu Lukaku in the 0-0 draw with Everton a week ago, but they insist that the Les Blues skipper was okay to continue.
However, Brad Friedel replaced him between the posts for Tottenham's midweek European fixture, and the American retains his place at White Hart Lane today, with the hosts seemingly unwilling to risk Lloris.
Friedel's inclusion for his 450th Premier League appearance, is one of four changes made by Andre Villas-Boas from the XI that started against the Toffees, with Christian Eriksen and Gylfi Sigurdsson returning in place of Aaron Lennon and Lewis Holtby.
Spurs: Friedel; Walker, Dawson, Chiriches, Vertonghen; Paulinho, Dembele; Sigurdsson, Eriksen, Townsend, Soldado
Subs: Gomes, Kaboul, Sandro, Lennon, Lamela, Holtby, Defoe
Newcastle: Krul; Debuchy, Williamson, Yanga-Mbiwa, Santon; Sissoko, Tiote, Cabaye, Gouffran; Ameobi, Remy
Subs: Elliot, Coloccini, Anita, Obertan, Sammy Ameobi, Ben Arfa, Cisse