The Hammers have won just one of their last 11 matches in all competitions but still sit relatively safely in mid-table.
Spurs, meanwhile, are just a point behind Chelsea in the race for a Champions League spot and have real ambitions of a top-four finish.
Ahead of Monday's match, West Ham chairman David Gold has pleaded with fans to not chant in an anti-semitic manner like they did at the reverse fixture in November that Spurs won 3-1.
Recent league form
West Ham: LDLLWL
Possible starting lineups
West Ham: Jaaskelainen; Demel, Collins, Reid; Pogatetz; Diame, Nolan, Noble; Cole, Carroll, Jarvis
Spurs: Lloris; Walker, Dawson, Vertonghen, Assou-Ekotto; Lennon, Parker, Dembele, Bale; Holtby; Dempsey
Sports Mole says: 1-3