The 29-year-old has already ruled Ben Davies out for the remainder of the season, while his fellow full-back Serge Aurier is "not 100%" as he attempts to shake off a groin problem, so he may not make the cut either.
Mason has no need to make any defensive alterations following their clean sheet against Wolverhampton Wanderers, as Eric Dier and Toby Alderweireld prepare to shield Hugo Lloris, who is supposedly set to pen a new deal with the Lilywhites.
Pierre-Emile Hojbjerg struck his second goal in a Tottenham shirt in Sunday's 2-0 win and will continue to man the midfield, most likely alongside Giovani Lo Celso, although Harry Winks is pushing for inclusion.
Mason talked up Dele Alli's performance against Wolves and is expected to stick with the Englishman in the number 10 role, with Gareth Bale and Son Heung-min once again providing support from the flanks, although the former will have to be checked to make sure he is OK for two starts in quick succession.
Harry Kane struck his 22nd league goal of the season last time out as he sits neck-and-neck with Mohamed Salah in the race for the Golden Boot, and Wednesday's game will mark the England captain's 400th appearance in club football.
Tottenham possible starting lineup: Lloris; Tanganga, Alderweireld, Dier, Reguilon; Hojbjerg, Lo Celso; Bale, Alli, Son; Kane
Watch the Sports Mole Football Shorts prediction for this game below: