Spurs have made an inconsistent start to the season and have taken seven points from their opening five games this term.
They were beaten 1-0 at home by West Browmich Albion in their last outing, and Pochettino thinks that changing the lineup based on the opposition will eventually yield results for his team.
He told reporters: "Our best starting team depends on each and every game - there is no doubt about that.
"It's not an excuse. A bad performance on Sunday is not because of the changes. We have a very strong squad and we need to use our players - we have a lot of games ahead and after each match we analyse every player.
"At the moment the players are not in a position to play three games in one week."
Pochettino's side host Nottingham Forest in the League Cup on Wednesday.