Spurs make the trip to the Etihad Stadium with City having recorded 15 successive victories in the top flight, with a new record being set in midweek.
Pochettino's side are 18 points adrift of the leaders, but the Argentine has acknowledged that he and his players are excited to take on Pep Guardiola's team in the North-West.
The 45-year-old told reporters: "There's always motivation to play this type of game. It's the type of game where you don't need to motivate the players, you don't need to talk to much.
"You can feel in the atmosphere after the Brighton game that they're so excited. For me, it's about enjoying it. You want to be there, you want to feel what happens on the touchline, feel what happens on the pitch.
"We're going to play, for me, the best team today in Europe, not only in England. Because they're in their best form. It's so exciting. It's a massive challenge - the type of challenge you always want the possibility to have."
Spurs have warmed up for the match in Manchester with back-to-back wins over Stoke City and Brighton & Hove Albion.