Spurs won at Old Trafford earlier in the season and the 25-year-old thinks that another big win could be on the cards.
Huddlestone also thinks that the side will take confidence after a good performance against Maribor in midweek.
"The win against Maribor probably gives us a bit of confidence that we have lacked," Huddlestone told the Daily Star. "I don't think that winning at City is unthinkable, we've had a fairly decent record there over the years.
"We want to sample the feeling we had at Old Trafford again. The result won't decide the title race but we are going there to win, and peg City back a bit.
"We will go to City with no fear."
Spurs face City at 1.30pm this afternoon.