Despite wanting his players to bounce back this weekend, Villas-Boas is aware that Villa can cause an another upset.
"We have been successful recently over there but it doesn't mean that you will be again, football changes very quickly," he told the club's official website.
"It's always difficult to play against Villa, a great, great stadium with lots of pressure.
"We are aware of their strengths and hopefully the team can respond in the right manner."
Tottenham can climb up to fifth place in the Premier League table with a win against Villa.