While the North London outfit's main objective at the start of the season was to reach Champions League qualification, Villas-Boas is confident that Spurs can close down the five-point gap separating themselves from the English title winners.
"[City] have the experience of winning the league, I think in their mind they are still focusing on it," Villas-Boas said in a press conference.
"They have to come here [to play us on April 21]. We have to play them still within this margin of five points at White Hart Lane. We could still put a threat to them. Our focus is on bridging gaps for the people in behind us."
Spurs are preparing to take on Arsenal in the North London derby on Sunday.