The winger missed Sunday's defeat to West Bromwich Albion in the Premier League with a dead leg.
Despite Townsend's return to fitness, Pochettino has refused to reveal whether the England international will start against Forest.
"Andros is fully fit and maybe has an opportunity to play," he told the club's official website. "Everyone else is okay, the squad is fit."
Spurs welcome Forest to White Hart Lane tomorrow night with a place in the fourth round of the competition at stake.