Spurs are without defeat in 11 top-flight encounters with Palace - their best run against any side in the division - and enter this game eight points better off in the table.
Out: Giovani Lo Celso (hamstring)
Sports Mole's predicted XI: Lloris; Aurier, Sanchez, Alderweireld, Reguilon; Hojbjerg, Ndombele; Bale, Lucas, Son; Kane
Out: James McArthur (muscle), Nathan Ferguson (thigh), Mamadou Sakho (thigh), James McCarthy (groin), Wayne Hennessey (thigh), James Tomkins (head)
Doubtful: Nathaniel Clyne (muscle), Tyrick Mitchell (knock), Wilfried Zaha (thigh)
Sports Mole's predicted XI: Guaita; Ward, Kouyate, Cahill, Van Aanholt; Townsend, Milivojevic, Riedewald, Eze; Benteke, Ayew
Watch the Sports Mole Football Shorts prediction for this game below: