Not since the reverse fixture on December 16, when going down 4-1 at the Etihad Stadium, have the Lilywhites tasted defeat in the top flight.
Here, Sports Mole looks at the options available to Pochettino for the visit of champions-elect City.
On the opposite flank, Kieran Trippier was rested for the 2-1 win against Stoke and may be restored in place of Serge Aurier, while Davinson Sanchez and Jan Vertonghen are now very much the first-choice central-defensive pairing.
Harry Kane's swifter-than-expected return from an ankle injury has been a big boost for Pochettino, and it seems certain that the Englishman will retain his spot through the middle this weekend, even if he has a pretty underwhelming goalscoring return against City.
The only other big decision comes in attacking midfield, where Erik Lamela and Lucas Moura are pushing for recalls to the starting lineup, but the form of Christian Eriksen, Dele Alli and Son Heung-min is keeping them out of the side.