Spurs earned a 1-1 draw at Camp Nou to secure their place in the last 16 on Tuesday night and now turn their attentions back to domestic duties, where they currently sit third in the Premier League table.
Ambitions of a possible title challenge continue to linger for a side that has won eight of their last 10 games across all competitions, and should results go their way this weekend then they could find themselves just three points off the leaders.
Here, Sports Mole looks at how Mauricio Pochettino could set his side up for the contest.
Spurs face a number of late fitness tests to determine who will be ready for this weekend's match, with particular problems coming in defence.
Kieran Trippier and Serge Aurier remain doubtful which means that Kyle Walker-Peters is likely to start again at right-back, while in the middle Davinson Sanchez and Juan Foyth are expected to miss out.
Christian Eriksen has been in and out of the team in recent weeks due to an ongoing stomach issue, but Pochettino has not outlined any concerns about the Dane ahead of this match so he should start.