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Spurs made several changes to their lineup having already established a five-goal lead in the first leg.
Defoe doubled his tally five minutes later when he tapped home from Gylfi Sigurdsson's cross.
It took until midway through the second half for Spurs to find the net again, and it was worth the wait. Holtby got on the scoresheet himself this time, thumping the ball in off the crossbar from 25-yards out.
Spurs saw the rest of the game out with ease against opponents who rarely threatened them.