Spurs earned their place in the third qualifying round of the competition with a hard-fought victory over Bulgarian outfit Lokomotiv Plovdiv last week.
Although Jose Mourinho watched his side follow up that win with the second-half demolition of Southampton at the weekend, the Portuguese has several important decisions to make regarding his team selection.
Here, Sports Mole predicts how Spurs could line up for their upcoming encounter against the North Macedonian outfit.
Although Mourinho has revealed that Dele Alli will feature in the travelling group, the playmaker is unlikely to earn a place in the starting lineup.
Sergio Reguilon could make his debut for the North Londoners at some stage in the match, providing that he is registered to feature at this stage of the competition.
Gareth Bale, who has joined Reguilon in leaving Real Madrid for Spurs, is due to spend the next few weeks on the sidelines with a knee injury.
Japhet Tanganga also remains unavailable as he continues his recovery from a thigh problem.