Cambiasso told UEFA.com: "Our performance was great from every point of view. We're sad to exit the competition, but we lost with dignity.
"I had a chance to score our fourth goal in the dying seconds of the second half, but it's not something I regret.
"It's not about a single chance to write history, it's about everything that happens throughout the match. I would be much more bothered had our performance been disappointing."
The draw for the quarter-finals of the Europa League will be made later today.