Also among the substitutes is Toby Alderweireld, who has been out with injury for nearly two months but is deemed fit enough for a place in the squad.
In his last game in charge of CSKA, head coach Leonid Slutsky makes two changes, with Kirill Nababkin replacing Mario Fernandes at right-back and Alan Dzagoev drafted into midfield at the expense of Fedor Chalov.
Tottenham Hotspur: Lloris, Walker, Dier, Vertonghen, Rose, Winks, Wanyama, Eriksen, Dele, Son, Kane
Subs: Vorm, Alderweireld, Wimmer, Dembele, Sissoko, Nkoudou, Onomah
CSKA Moscow: Akinfeev, Nababkin, A. Berezutskiy, V. Berezutskiy, Shchennikov, Natcho, Golovin, Tosic, Milanov, Dzagoev, Traore
Subs: Chepchugov, Ignashevich, Gordyushenko, Chalov, Strandberg
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