Howe is now eager to add Tottenham's name to a list of big-name scalps after overcoming both Arsenal and champions Chelsea in the Premier League since the turn of the year.
"They have been playing really well lately and are on a really good unbeaten run," he said at Friday's pre-match press conference. "The [Champions League] exit will have really hurt them, they were the best team for the majority of that game.
"But being at home, we have to focus on ourselves. Since Christmas we have been very strong and have beaten some big teams here.
"I think we are capable of beating anybody here. We have beaten some very good teams - the crowd get behind us and we make it very difficult for opposing teams."
Bournemouth have taken 19 points from their 14 games at the Vitality Stadium this term, placing them 14th in the home form table.